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The business realm is not solely confined to obtaining human capital and involving them in their professional lives. Another vital aspect of business organizations is the significance of employee engagement, employees’ readiness to change. Prior to introducing any alterations within the organization, those leading the change, or change agents, need to impact the employees' readiness for change. This involves comprehending the factors that drive change and foster a state of preparedness for it.This research study looked at the nature of the connection between job satisfaction (JS), employees’ readiness to change (ERTC), and transformational leadership (TFL) within the workforce of the Indian Pharmaceutical sector. It also presented a conceptual model and the link between TFL and JS was studied in regard to the mediating role of ERTC. The validity of the conceptual model was confirmed through the utilisation of partial least squares structural equation modeling (PLS-SEM). Purposive and convenient sampling employed 254 individuals in the Delhi-NCR's. The results indicated a substantial and significant positive relationship between ERTC and TFL and JS. It was discovered that ERTC mediates the link between TFL and JS. The results verify that HR departments and policymakers have a direct impact on TFL and ERTC through organizational actions. Additionally, it has the impact of raising employees' positive attitudes and levels of satisfaction with their employment. This latest research contributes to the expanding field of studies concerning ERTC, TFL, and JS, which is continually increasing.